The 25th European Conference on Computational Biology (ECCB 2026) will take place in Geneva from 31 August to 4 September 2026. Organized by the SIB Swiss Institute of Bioinformatics, the conference will explore advancements in genomics, structural bioinformatics, systems biology, biodiversity, and more under the theme 'Biodiversity, AI & Health: computational biology to address the challenges of our time'. The programme includes keynotes, proceedings, highlight talks, poster sessions, tutorials, workshops, and networking events.