The annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the flagship meeting of the International Society for Computational Biology (ISCB). The 2026 meeting is the 34th ISMB conference, which has grown to become the world's largest bioinformatics and computational biology conference. ISMB 2026 will be the year's most important computational biology event! The principal focus of the ISMB conference is on the development and application of advanced computational methods to address biological problems, and it brings together researchers from computer science, bioinformatics, computational biology, molecular biology, mathematics, statistics, and related fields.